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Dermal fillers are injected under the skin to smooth lines or add fullness to the face or hands. Botox is injected into specific muscles to relax them. It can be used to flatten wrinkles as well as a number of other medical conditions. What is better Botox or fillers? Compared to Botox, dermal fillers are just as effective. More importantly, the results last longer. However, the duration of the effects of dermal fillers still varies mostly on the type of filler. Some may last as long as Botox, while other types of fillers can last for more than a year.